Weisser B, Mengden T, Vetter W
Universitätsspital Zürich, Medizinische Poliklinik, Switzerland.
J Hypertens Suppl. 1990 Dec;8(6):S87-92.
Until a few years ago, only casual blood pressure measurements were used in the diagnosis and treatment of arterial hypertension in clinical practice and in pharmacological studies. The development of portable lightweight devices for 24-h ambulatory blood pressure measurement has proved a substantial step towards reducing the potential pitfalls of casual blood pressure measurements. Ambulatory monitoring of blood pressure can improve pharmacological trials by excluding patients in whom blood pressure is elevated only in the clinic environment, and by increasing the accuracy and reproducibility of blood pressure values. Twenty-four-hour blood pressure measurement has great advantages for trials investigating the time-course of a particular drug, since the 24-h blood pressure rhythm is fully monitored. However, internationally accepted normal values for 24-h blood pressure measurements are required, and the interpretation of results obtained with this method needs to be standardized before the technique can be routinely used in antihypertensive drug trials.
直到几年前，在临床实践和药理研究中，动脉高血压的诊断和治疗仅采用偶尔测量血压的方法。用于24小时动态血压测量的便携式轻便设备的开发，已证明是朝着减少偶尔测量血压潜在缺陷迈出的重要一步。动态血压监测可以通过排除仅在临床环境中血压升高的患者，以及提高血压值的准确性和可重复性来改进药理试验。24小时血压测量对于研究特定药物的时间进程的试验具有很大优势，因为可以全面监测24小时血压节律。然而，需要有国际公认的24小时血压测量正常值，并且在该技术能够常规用于抗高血压药物试验之前，需要对用这种方法获得的结果的解释进行标准化。
