Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Chem Soc Rev. 2010 Oct;39(10):3843-62. doi: 10.1039/b926164h. Epub 2010 Aug 31.
Anions cannot diffuse passively through biological membranes and membrane-bound proteins mainly govern the transmembrane movement of these charged species. The use of synthetic compounds that are able to facilitate the transmembrane transport of anions is a fascinating and burgeoning topic. The study of facilitated anion transport across lipid bilayers is an emerging field in supramolecular and bioorganic chemistry. In this critical review we describe the recent research progress in this area, focusing on literature published during the years 2007-2009. An overview of the assays that are used in the transmembrane transport of anions is also included (158 references).
阴离子不能被动扩散通过生物膜，而膜结合蛋白主要控制这些带电物质的跨膜运动。使用能够促进阴离子跨膜转运的合成化合物是一个令人着迷且新兴的课题。在超分子和生物有机化学领域，研究脂双层中阴离子的促进转运是一个新兴领域。在这篇评论中，我们描述了该领域的最新研究进展，重点介绍了 2007 年至 2009 年期间发表的文献。本文还概述了用于阴离子跨膜转运的测定方法（158 篇参考文献）。
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