甲状腺激素对显性甲状腺功能减退的非糖尿病患者 A1C 和糖化白蛋白水平的影响。
Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism.
机构信息
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
出版信息
Diabetes Care. 2010 Dec;33(12):2546-8. doi: 10.2337/dc10-0988. Epub 2010 Sep 7.
OBJECTIVE
We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism.
RESEARCH DESIGN AND METHODS
A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement.
RESULTS
A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered.
CONCLUSIONS
Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.
目的
我们旨在确定甲状腺激素对显性甲状腺功能减退症非糖尿病患者的糖化血红蛋白（A1C）和糖化白蛋白（GA）的影响。
研究设计和方法
在 45 名显性甲状腺功能减退症的非糖尿病患者和 180 名甲状腺功能正常的对照组中测量了 A1C 水平。在 30 名显性甲状腺功能减退症的非糖尿病患者中，测定了甲状腺激素替代治疗前后的 A1C、GA、空腹血糖（FBG）、1,5-脱水葡萄糖醇和红细胞指数。
结果
与对照组相比，甲状腺功能减退症患者的 A1C 水平更高。甲状腺激素替代治疗可降低 A1C 水平。甲状腺激素替代治疗增加了血清促红细胞生成素、网织红细胞计数和平均红细胞血红蛋白（MCH）。A1C 水平的变化与网织红细胞计数或 MCH 的变化显著相关。甲状腺激素替代治疗降低了血清白蛋白和 GA 水平。然而，FBG 和 1,5-脱水葡萄糖醇水平没有改变。
结论
显性甲状腺功能减退症非糖尿病患者的 A1C 和 GA 水平偏高。
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