Shuvalova E P, Polotskiĭ V Iu
Klin Med (Mosk). 1990 Dec;68(12):49-51.
Clinical evidence and morphological picture of rectal biopsy specimens were analysed for 125 dysentery patients. As compared to a light course, moderately severe and severe dysentery presented enhanced microbial adherence and an elevated level of large lymphocytes in the external epithelium of the rectum, deeper penetration of Shigella into crypts. On day 9-15 of the disease in attenuation of the clinical symptoms in severe and moderately dysentery morphological shifts persisted whereas the light run was associated with a marked decline of microbial invasion and cellular infiltration of the epithelium. In the protracted condition elimination of the microbes with desquamative colonocytes appeared inhibited permitting prognosis of the protraction as early as day 2-4 of the disease.
对125例痢疾患者的直肠活检标本的临床证据和形态学图片进行了分析。与轻度病程相比,中度严重和严重痢疾表现为微生物黏附增强、直肠外上皮中大淋巴细胞水平升高、志贺菌向隐窝的更深浸润。在疾病的第9 - 15天,严重和中度痢疾临床症状减轻时形态学改变持续存在,而轻度病程则与微生物侵袭的显著下降和上皮细胞浸润有关。在迁延性病情中,微生物随脱屑结肠上皮细胞的清除似乎受到抑制,这使得早在疾病的第2 - 4天就能对病程迁延作出预后判断。