Department of Physical Therapy, Biomechanical Research Laboratory, Tarbiat Modares University, Tehran, Tehran, Iran.
Haemophilia. 2011 Jan;17(1):124-33. doi: 10.1111/j.1365-2516.2010.02375.x. Epub 2010 Sep 22.
Changes in articular cartilage after haemarthrosis have not been completely elucidated in haemophilic arthropathy. Insights into the pathophysiological mechanisms of blood-induced joint damage mainly derived from histological, inflammatory and biochemical investigations. A structure-function relationship is another reasonable way to determine the joint overall health status. Cartilage, a viscoelastic connective tissue, is at least a biphasic material that should also work under minimal friction. Pendulum friction tester measures the mechanical aspects of joint lubrication and quantifies the biotribological properties of the joint. Indentation test is an in situ method characterizing the biomechanical properties of the cartilage. Gross, biotribological and biomechanical properties were determined in a rabbit model of experimental haemarthrosis. A sample of 1 mL of fresh autologous blood was injected in the left knee of rabbit's joint twice weekly for four consecutive weeks. The right knee and animals in the control group were left untreated. After 8 days, joint perimeter, biotribological and biomechanical tests were performed. In a consistent manner, all data showed detrimental effects of the blood on the overall cartilage function under loading. Non-weight bearing and early blood aspiration seem wise to be considered after haemarthrosis.
在血友病性关节病中，关节软骨在关节积血后的变化尚未完全阐明。对血液引起的关节损伤的病理生理机制的深入了解主要来自组织学、炎症和生化研究。结构-功能关系是另一种确定关节整体健康状况的合理方法。软骨是一种粘弹性结缔组织，至少是一种双相材料，也应该在最小摩擦下工作。摆式摩擦试验机测量关节润滑的力学方面，并量化关节的生物摩擦学特性。压痕试验是一种原位方法，用于表征软骨的生物力学特性。在实验性关节积血的兔模型中确定了大体、生物摩擦学和生物力学特性。每周两次向兔关节的左膝注射 1 毫升新鲜自体血，连续 4 周。右膝和对照组动物未接受治疗。8 天后，进行关节周长、生物摩擦学和生物力学测试。所有数据都一致表明，在加载下，血液对整体软骨功能有不利影响。在关节积血后，非负重和早期血液抽吸似乎是明智的。
