芬兰男性和女性的职业、通勤和休闲时间体力活动与心力衰竭的关系。
Occupational, commuting, and leisure-time physical activity in relation to heart failure among finnish men and women.
机构信息
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
出版信息
J Am Coll Cardiol. 2010 Sep 28;56(14):1140-8. doi: 10.1016/j.jacc.2010.05.035.
OBJECTIVES
The purpose of this study was to examine the association of different levels of occupational, commuting, and leisure-time physical activity and heart failure (HF) risk.
BACKGROUND
The role of different types of physical activity in explaining the risk of HF is not properly established.
METHODS
Study cohorts included 28,334 Finnish men and 29,874 women who were 25 to 74 years of age and free of HF at baseline. Baseline measurement of different types of physical activity was used to predict incident HF.
RESULTS
During a mean follow-up of 18.4 years, HF developed in 1,868 men and 1,640 women. The multivariate adjusted (age; smoking; education; alcohol consumption; body mass index; systolic blood pressure; total cholesterol; history of myocardial infarction, valvular heart disease, diabetes, lung disease, and use of antihypertensive drugs; and other types of physical activity) hazard ratios of HF associated with light, moderate, and active occupational activity were 1.00, 0.90, and 0.83 (p = 0.005, for trend) for men and 1.00, 0.80, and 0.92 (p = 0.007, for trend) for women, respectively. The multivariate adjusted hazard ratios of HF associated with low, moderate, and high leisure-time physical activity were 1.00, 0.83, and 0.65 (p < 0.001, for trend) for men and 1.00, 0.84, and 0.75 (p < 0.001, for trend) for women, respectively. Active commuting had a significant inverse association with HF risk in women, but not in men, before adjustment for occupational and leisure-time physical activity. The joint effects of any 2 types of physical activity on HF risk were even greater.
CONCLUSIONS
Moderate and high levels of occupational or leisure-time physical activity are associated with a reduced risk of HF.
目的
本研究旨在探讨不同水平的职业、通勤和休闲时间体力活动与心力衰竭（HF）风险的关联。
背景
不同类型的体力活动在解释 HF 风险中的作用尚未得到充分确立。
方法
研究队列包括 28334 名芬兰男性和 29874 名年龄在 25 至 74 岁且基线时无 HF 的女性。使用不同类型体力活动的基线测量来预测 HF 的发生。
结果
在平均 18.4 年的随访期间，1868 名男性和 1640 名女性发生 HF。多变量调整（年龄；吸烟；教育；饮酒；体重指数；收缩压；总胆固醇；心肌梗死、瓣膜性心脏病、糖尿病、肺部疾病和使用抗高血压药物的病史；以及其他类型的体力活动）后，男性中与轻度、中度和积极职业活动相关的 HF 的风险比分别为 1.00、0.90 和 0.83（p=0.005，趋势），女性中分别为 1.00、0.80 和 0.92（p=0.007，趋势）。多变量调整后，男性中与低、中、高强度休闲时间体力活动相关的 HF 的风险比分别为 1.00、0.83 和 0.65（p<0.001，趋势），女性中分别为 1.00、0.84 和 0.75（p<0.001，趋势）。在调整职业和休闲时间体力活动之前，积极的通勤与女性 HF 风险呈显著负相关，但在男性中则不然。任何两种体力活动的联合效应对 HF 风险的影响更大。
结论
中等和高强度的职业或休闲时间体力活动与 HF 风险降低相关。
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