高区域选择性的螯合烯醇化物的钌催化烯丙基烷基化反应。

Highly regioselective ruthenium-catalyzed allylic alkylations of chelated enolates.

机构信息

Universität des Saarlandes, Institut für Organische Chemie, Im Stadtwald, Geb. 23.2, D-66123 Saarbrücken, Germany.

出版信息

Org Lett. 2010 Nov 5;12(21):4960-3. doi: 10.1021/ol102106v.

PMID:20866103

Abstract

Ru-catalyzed allylic alkylations are a highly interesting alternative to Pd-catalyzed reactions. Ru complexes show a high tendency for regioretention, especially for branched and (Z)-configured substrates, and they do not undergo isomerization of the allyl intermediates formed. Therefore, (Z)-substrates conserve their olefin geometry, and a perfect chirality transfer is observed with optically active substrates.

摘要

钌催化的烯丙基烷基化反应是钯催化反应的一种很有吸引力的替代方法。钌配合物具有高区域选择性，特别是对于支链和（Z）构型的底物，并且它们不会经历形成的烯丙基中间体的异构化。因此，（Z）底物保留其烯烃几何形状，并且用光学活性底物观察到完美的手性转移。