Benavides Valeria C, Rivkees Scott A
Section of Endocrinology, Department of Pediatrics, Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Int J Pediatr Endocrinol. 2010;2010. doi: 10.1155/2010/717303. Epub 2010 Sep 14.
We describe acute myopathy following I-131 treatment for hyperthyroidism due to Graves Disease (GD) in an adolescent. A 15 year-old diagnosed with GD required treatment with radioactive iodine (I-131) therapy. Six weeks post I-131, he developed generalized muscle cramps. The CK was 19.800 U/L, the total thyroxine was 2.3 mcg/dL (29.6 nmol/L SI) and the estimated free thyroxine (EFT) was 0.5 ng/dL (6.4 pmol/L SI). The ALT was 112 U/L and AST was 364 U/L (normal <35 U/L). The muscle cramps and CK elevation normalized five months after initiation of thyroid replacement therapy. This observation shows that acute myopathy can rarely occur in pediatric patients with GD following treatment with I-131.
我们描述了一名青少年因格雷夫斯病（GD）接受碘-131治疗甲亢后出现的急性肌病。一名15岁被诊断为GD的患者需要接受放射性碘（I-131）治疗。I-131治疗六周后，他出现了全身性肌肉痉挛。肌酸激酶（CK）为19800 U/L，总甲状腺素为2.3 mcg/dL（29.6 nmol/L SI），估计游离甲状腺素（EFT）为0.5 ng/dL（6.4 pmol/L SI）。谷丙转氨酶（ALT）为112 U/L，谷草转氨酶（AST）为364 U/L（正常<35 U/L）。甲状腺替代治疗开始五个月后，肌肉痉挛和CK升高恢复正常。该观察结果表明，GD儿童患者接受I-131治疗后很少会发生急性肌病。
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