日本农村地区帕金森病和非典型帕金森综合征的患病率。
Prevalence of Parkinson's disease and atypical parkinsonian syndromes in a rural Japanese district.
机构信息
Department of Geriatrics, Cardiology and Neurology, Kochi Medical School, Nankoku, Japan.
出版信息
Acta Neurol Scand. 2011 Sep;124(3):182-7. doi: 10.1111/j.1600-0404.2010.01442.x. Epub 2010 Sep 29.
OBJECTIVES
To investigate the prevalence of Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) in a rural Japanese district.
METHOD
Collaboration with the medical institutions, the long-term care insurance system facilities, and the public health office.
RESULTS
The crude prevalence rates were 175 per 100,000 (95% CI: 143-206) for PD, 18 (8-28) for progressive supranuclear palsy, 17 (7-26) for multiple system atrophy (MSA), and 9 (2-16) for corticobasal degeneration. The age-adjusted prevalence rates were 109 per 100,000 (88-134), 10 (2-17), 13 (4-21), and 6 (0-12), for each condition. There was a preponderance of women with PD and of men with APS. Nine of the 116 PD patients and 7 of the 29 APS patients were newly diagnosed in this study.
CONCLUSIONS
There are high prevalence rates for PD and APS and suboptimal recognition of APS. This is the first epidemiological prevalence study of MSA from Japan.
目的
调查日本农村地区帕金森病（PD）和不典型帕金森综合征（APS）的患病率。
方法
与医疗机构、长期护理保险制度设施和公共卫生办公室合作。
结果
PD 的粗患病率为 175/100,000（95%CI：143-206），进行性核上性麻痹为 18（8-28），多系统萎缩为 17（7-26），皮质基底节变性为 9（2-16）。经年龄调整后的患病率分别为 109/100,000（88-134）、10（2-17）、13（4-21）和 6（0-12）。PD 患者中女性居多，APS 患者中男性居多。116 名 PD 患者中有 9 名和 29 名 APS 患者中有 7 名是在本研究中确诊的新病例。
结论
PD 和 APS 的患病率较高，对 APS 的认识不足。这是日本首例 MSA 的流行病学患病率研究。
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