心房利钠肽的作用及其治疗用途。

Roles of atrial natriuretic peptide and its therapeutic use.

机构信息

First Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

出版信息

J Cardiol. 2010 Nov;56(3):262-70. doi: 10.1016/j.jjcc.2010.08.001. Epub 2010 Sep 29.

DOI:10.1016/j.jjcc.2010.08.001

PMID:20884176

Abstract

Since the discovery of atrial natriuretic peptide (ANP), there has been tremendous progress in our understanding of the physiologic and pathophysiologic, diagnostic, and therapeutic roles of ANP. The diagnostic application of ANP and brain natriuretic peptide (BNP) has been reviewed by many investigators, and meta-analyses of therapeutic use of BNP were reported from the USA. However, there are few reviews concerning the therapeutic use of ANP in patients with various conditions. Therefore, this review focuses on the recent clinical evidence of ANP in therapeutic use and experimental data that rationally support the therapeutic use of ANP.

摘要

自从发现心房利钠肽（ANP）以来，我们对 ANP 的生理和病理生理、诊断和治疗作用的理解取得了巨大进展。许多研究人员已经对 ANP 和脑利钠肽（BNP）的诊断应用进行了综述，并且来自美国的研究人员也报道了 BNP 治疗用途的荟萃分析。然而，关于各种情况下 ANP 治疗用途的综述很少。因此，本综述重点介绍了 ANP 治疗用途的最新临床证据和合理支持 ANP 治疗用途的实验数据。