大蜡螟对烟曲霉感染有抵抗力。
Galleria mellonella are resistant to Pneumocystis murina infection.
机构信息
Division of Infectious Diseases, Massachusetts General Hospital, Gray-Jackson 504, 55 Fruit Street, Boston, MA 02114, USA.
出版信息
Mycopathologia. 2011 Apr;171(4):273-7. doi: 10.1007/s11046-010-9368-4. Epub 2010 Oct 5.
Abstract
Studying Pneumocystis has proven to be a challenge from the perspective of propagating a significant amount of the pathogen in a facile manner. The study of several fungal pathogens has been aided by the use of invertebrate model hosts. Our efforts to infect the invertebrate larvae Galleria mellonella with Pneumocystis proved futile since P. murina neither caused disease nor was able to proliferate within G. mellonella. It did, however, show that the pathogen could be rapidly cleared from the host.
摘要
从简便地繁殖大量病原体的角度来看，研究肺孢子菌一直是一个挑战。几种真菌病原体的研究得益于使用无脊椎动物模型宿主。我们试图用肺孢子菌感染无脊椎动物幼虫家蚕，但未能成功，因为肺孢子菌既不会引起疾病，也无法在 G. mellonella 中增殖。然而，它确实表明病原体可以从宿主中迅速清除。
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2
Pneumocystis encodes a functional S-adenosylmethionine synthetase gene.
Eukaryot Cell. 2008 Feb;7(2):258-67. doi: 10.1128/EC.00345-07. Epub 2007 Dec 7.
3
Using non-mammalian hosts to study fungal virulence and host defense.
Curr Opin Microbiol. 2006 Aug;9(4):346-51. doi: 10.1016/j.mib.2006.06.004. Epub 2006 Jun 30.
4
Serial passage of the opportunistic pathogen Aspergillus flavus through an insect host yields decreased saprobic capacity.
Can J Microbiol. 2005 Feb;51(2):185-9. doi: 10.1139/w04-124.
5
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Infect Immun. 2005 Jul;73(7):3842-50. doi: 10.1128/IAI.73.7.3842-3850.2005.
6
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Mycopathologia. 2004 Jul;158(1):73-9. doi: 10.1023/b:myco.0000038434.55764.16.
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J Infect Dis. 2004 Apr 15;189(8):1540-4. doi: 10.1086/382486. Epub 2004 Apr 2.
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