基于单金纳米星的无标记生物传感的等离子体换能器。

Label-free biosensing based on single gold nanostars as plasmonic transducers.

机构信息

Photonics and Optoelectronics Group, Physics Department and Center for Nanoscience (CeNS), Ludwig-Maximilians-Universität München, Amalienstrasse 54, 80799 Munich, Germany.

出版信息

ACS Nano. 2010 Nov 23;4(11):6318-22. doi: 10.1021/nn100760f. Epub 2010 Oct 13.

DOI:10.1021/nn100760f

PMID:20942444

Abstract

Gold nanostars provide high sensitivity for single nanoparticle label-free biosensing. The nanostars present multiple plasmon resonances of which the lower energy ones, corresponding to the nanostar tips and core-tip interactions, are the most sensitive to environmental changes. Streptavidin molecules are detected upon binding to individual, biotin-modified gold nanostars by spectral shifts in the plasmon resonances. Concentrations as low as 0.1 nM produce a shift of the tip related plasmon resonances of about 2.3 nm (5.3 meV).

摘要

金纳米星为单颗粒无标记生物传感提供了高灵敏度。纳米星呈现出多个等离子体共振，其中能量较低的共振对应于纳米星尖端和核尖端相互作用，对环境变化最为敏感。当单个生物素修饰的金纳米星结合时，通过等离子体共振的光谱位移来检测链霉亲和素分子。浓度低至 0.1 nM 时，大约会使尖端相关等离子体共振发生 2.3nm（5.3meV）的位移。