Santanasto Adam J, Glynn Nancy W, Newman Mark A, Taylor Christopher A, Brooks Maria Mori, Goodpaster Bret H, Newman Anne B
Department of Epidemiology, Graduate School of Public Health, Center for Aging and Population Health, University of Pittsburgh, 130 N. Bellefield Avenue, Pittsburgh, PA 15260, USA.
J Obes. 2011;2011. doi: 10.1155/2011/516576. Epub 2010 Oct 10.
Purpose. Evaluate the effects of weight loss on muscle mass and area, muscle fat infiltration, strength, and their association with physical function. Methods. Thirty-six overweight to moderately obese, sedentary older adults were randomized into either a physical activity plus weight loss (PA+WL) or physical activity plus successful aging health education (PA+SA) program. Measurements included body composition by dual-energy X-ray absorptiometry, computerized tomography, knee extensor strength, and short physical performance battery (SPPB). Results. At 6 months, PA+WL lost greater thigh fat and muscle area compared to PA+SA. PA+WL lost 12.4% strength; PA+SA lost 1.0%. Muscle fat infiltration decreased significantly in PA+WL and PA+SA. Thigh fat area decreased 6-fold in comparison to lean area in PA+WL. Change in total SPPB score was strongly inversely correlated with change in fat but not with change in lean or strength. Conclusion. Weight loss resulted in additional improvements in function over exercise alone, primarily due to loss of body fat.
目的。评估体重减轻对肌肉质量和面积、肌肉脂肪浸润、力量及其与身体功能关联的影响。方法。36名超重至中度肥胖、久坐不动的老年人被随机分为体育活动加体重减轻（PA+WL）组或体育活动加成功老龄化健康教育（PA+SA）组。测量包括通过双能X线吸收法进行的身体成分分析、计算机断层扫描、膝伸肌力量以及简短体能测试电池（SPPB）。结果。6个月时，与PA+SA相比，PA+WL组大腿脂肪和肌肉面积减少更多。PA+WL组力量下降12.4%；PA+SA组下降1.0%。PA+WL组和PA+SA组肌肉脂肪浸润均显著减少。在PA+WL组中，大腿脂肪面积与瘦组织面积相比减少了6倍。SPPB总分的变化与脂肪变化呈强烈负相关，与瘦组织或力量变化无关。结论。体重减轻导致在单独运动基础上功能进一步改善，主要是由于身体脂肪减少。
