Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 32602, USA.
J Vet Intern Med. 2010 Nov-Dec;24(6):1475-82. doi: 10.1111/j.1939-1676.2010.0621.x. Epub 2010 Oct 19.
Hepatic failure is one of the more common complications in foals requiring blood transfusion to treat neonatal isoerythrolysis. Iron intoxication is likely the cause of hepatic injury.
To determine the effects of deferoxamine on iron elimination in normal foals.
Thirteen neonatal foals.
Randomized-controlled trial. At 1-3 days of age, foals received either 3 L of washed packed dam's red blood cells (RBC) or 3 L of saline IV once. Foals were treated with deferoxamine (1 g) or saline (5 mL) SC twice daily for 14 days. Foals were randomly assigned to 1 of 3 groups: RBC/deferoxamine (deferoxamine), RBC/saline (placebo), or saline/saline (control). Blood and urine samples and liver biopsy specimens were collected for measurement of hematological, biochemical, and iron metabolism variables.
There was a significant (P<.05) increase in hematocrit, RBC count, and hemoglobin in the groups transfused with packed RBC as compared with controls at all times. Biochemical variables and liver biopsy scores were not significantly different between groups at any time. Urine iron concentrations and fractional excretion of iron were significantly higher in deferoxamine treated foals. By 14 days after transfusion, liver iron concentrations in foals treated with deferoxamine (79.9±30.9 ppm) were significantly lower than that of foals receiving placebo (145±53.0 ppm) and similar to that of controls (44.8±4.09 ppm).
Deferoxamine enhances urinary iron elimination and decreases hepatic iron accumulation after blood transfusion in foals.
肝衰竭是接受输血治疗新生儿同种免疫溶血病的马驹常见并发症之一。铁中毒可能是肝损伤的原因。
确定去铁胺对正常驹铁排泄的影响。
13 头新生驹。
随机对照试验。在 1-3 日龄时，驹接受 3 L 洗涤后的母马浓缩红细胞（RBC）或 3 L 盐水 IV 输注，一次。驹接受去铁胺（1 g）或盐水（5 mL）皮下注射，每天 2 次，持续 14 天。驹随机分为 3 组：RBC/去铁胺（去铁胺）、RBC/盐水（安慰剂）或盐水/盐水（对照）。采集血液和尿液样本以及肝活检标本，用于测量血液学、生化和铁代谢变量。
与对照组相比，所有时间点输注浓缩 RBC 的组的红细胞压积、RBC 计数和血红蛋白均显著增加（P<.05）。任何时间点各组的生化变量和肝活检评分均无显著差异。去铁胺治疗驹的尿铁浓度和铁排泄分数明显较高。在输血后 14 天，接受去铁胺治疗的驹的肝脏铁浓度（79.9±30.9 ppm）明显低于接受安慰剂治疗的驹（145±53.0 ppm），与对照组相似（44.8±4.09 ppm）。
去铁胺可增强输血后驹的尿铁排泄，并减少肝脏铁蓄积。
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