Chen Qian, Gu Yonghong, Zhou Changju, Hu Lingyu, Peng Changying
Department of Pathology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Oct;35(10):1073-9. doi: 10.3969/j.issn.1672-7347.2010.10.007.
To investigate the expression of Calponin-1 and Transgenlin in the uterine smooth muscles during normal labor on-sets, and to evaluate their effect on initiating the normal labor.
A total of 14 uterine bodies and lower segments of human pregnancy were divided to a non-labor group (NIL) and a labor group(IL). Immunohistochemical technology and Western blot were used to determine the expression of Calponin-1 and Transgelin in the 2 groups.
Immunohistochemical detection and Western blot showed that Calponin-1 protein in the uterine smooth muscle tissue of the body and the lower uterine segment of smooth muscle tissues had significant difference (P<0.05). The expression of Transgelin in the uterine body smooth muscle tissue in the IL was higher than that in the NIL(P<0.05). In the lower uterine segments of the smooth muscle, the expression of Transgelin was not significantly different in the 2 groups (P>0.05).
Calponin-1 of the uterine smooth muscle and Transgelin of the uterine body smooth muscle may involve in the regulation of uterine smooth muscle contractility, which is closely related to child birth launch.
探讨正常分娩发动时子宫平滑肌中钙调蛋白-1（Calponin-1）和转胶蛋白（Transgenlin）的表达情况，并评估它们对启动正常分娩的作用。
选取14例人妊娠子宫体及下段组织，分为未临产组（NIL）和临产组（IL）。采用免疫组织化学技术和蛋白质印迹法检测两组中钙调蛋白-1和转胶蛋白的表达。
免疫组织化学检测和蛋白质印迹法显示，子宫体平滑肌组织及子宫下段平滑肌组织中钙调蛋白-1蛋白表达有显著差异（P<0.05）。临产组子宫体平滑肌组织中转胶蛋白表达高于未临产组（P<0.05）。在子宫下段平滑肌中，两组中转胶蛋白表达无显著差异（P>0.05）。
子宫平滑肌中的钙调蛋白-1和子宫体平滑肌中的转胶蛋白可能参与子宫平滑肌收缩力的调节，这与分娩发动密切相关。
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