三氯化铟催化的三组分偶联反应：新型 2-取代芳基（吲哚基）洛索酸衍生物的合成及其作为强效抗真菌和抗菌剂的研究。
Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents.
机构信息
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India.
出版信息
Bioorg Med Chem Lett. 2010 Dec 15;20(24):7507-11. doi: 10.1016/j.bmcl.2010.10.003. Epub 2010 Oct 14.
PMID:21067928
Abstract
Three-component coupling of aldehyde, indole and kojic acid has been achieved using a catalytic amount of InCl(3) under solvent free conditions to produce a novel series of 2-substituted aryl(indolyl)kojic acid derivatives in good yields and with high selectivity. These compounds are found to exhibit potent antifungal properties.
摘要
在无溶剂条件下，使用催化量的三氯化铟（InCl(3)）实现了醛、吲哚和曲酸的三组分偶联，以高产率和高选择性得到了一系列新型的 2-取代芳基（吲哚基）曲酸衍生物。这些化合物表现出很强的抗真菌活性。
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