抗丙烯醛治疗可改善实验性自身免疫性脑脊髓炎小鼠的行为学结果并减轻髓鞘损伤。
Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse.
机构信息
Department of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Neuroscience. 2011 Jan 26;173:150-5. doi: 10.1016/j.neuroscience.2010.11.018. Epub 2010 Nov 26.
Abstract
Oxidative stress is considered a major contributor in the pathology of multiple sclerosis (MS). Acrolein, a highly reactive aldehyde byproduct of lipid peroxidation, is thought to perpetuate oxidative stress. In this study, we aimed to determine the role of acrolein in an animal model of MS, experimental autoimmune encephalomyelitis (EAE) mice. We have demonstrated a significant elevation of acrolein protein adduct levels in EAE mouse spinal cord. Hydralazine, a known acrolein scavenger, significantly improved behavioral outcomes and lessened myelin damage in spinal cord. We postulate that acrolein is an important pathological factor and likely a novel therapeutic target in MS.
摘要
氧化应激被认为是多发性硬化症 (MS) 病理的主要原因。丙烯醛是脂质过氧化的一种高反应性醛类副产物，被认为会持续引发氧化应激。在这项研究中，我们旨在确定丙烯醛在实验性自身免疫性脑脊髓炎 (EAE) 小鼠的 MS 动物模型中的作用。我们已经证明丙烯醛蛋白加合物水平在 EAE 小鼠脊髓中显著升高。肼屈嗪是一种已知的丙烯醛清除剂，可显著改善行为结果并减轻脊髓中的髓鞘损伤。我们推测丙烯醛是一个重要的病理因素，并且可能是 MS 的一个新的治疗靶点。
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