血小板计数和红细胞沉降率是川崎病的良好预测指标：ROC 分析。
Platelet count and erythrocyte sedimentation rate are good predictors of Kawasaki disease: ROC analysis.
机构信息
Clinical Laboratory Department, The First Hospital Affiliated to Xiamen University, Xiamen, China.
出版信息
J Clin Lab Anal. 2010;24(6):385-8. doi: 10.1002/jcla.20414.
BACKGROUND AND AIMS
Kawasaki disease (KD) is the leading cause of acquired pediatric cardiac disease and requires a timely diagnosis. Available effective therapy is ideally administered within 10 days of illness diagnosis. Recent reports of several laboratory tests in KD have been published. In this study, we aimed to evaluate the sensitivity and specificity of several laboratory tests.
METHODS
We performed a retrospective study of consecutive patients diagnosed with KD from January to December 2008. We studied the sensitivity and specificity of several different tests [T-cell subgroups, platelet count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)] to predict KD using receiver operator characteristic curve analysis.
RESULTS
No significant difference was demonstrated in T-cell subgroups between patients with KD and referent patients (P>0.05). However, platelet count, ESR, and CRP were significantly higher in patients with KD than in referent patients (P<0.05). ESR showed a sensitivity of 93.9% and specificity of 83.3% with a cut-off of 15 mm/hr (area under the curve [AUC], 89.1%; P=0.03). Platelet count showed a sensitivity of 70.6% and specificity of 75% with a cut-off of 336.5×10(9)/l (AUC, 71.2%; P=0.03).
CONCLUSIONS
These results indicate that platelet count and ESR are good predictors of KD.
背景与目的
川崎病（KD）是导致儿童后天性心脏病的主要原因，需要及时诊断。理想情况下，在发病后 10 天内给予有效的治疗。最近有几项关于 KD 的实验室检测的报告已经发表。在本研究中，我们旨在评估几项实验室检测的敏感性和特异性。
方法
我们对 2008 年 1 月至 12 月期间连续被诊断为 KD 的患者进行了回顾性研究。我们使用受试者工作特征曲线分析，研究了几种不同的检测方法[T 细胞亚群、血小板计数、红细胞沉降率（ESR）和 C 反应蛋白（CRP）]对预测 KD 的敏感性和特异性。
结果
KD 患者和参照患者之间的 T 细胞亚群无显著差异（P>0.05）。然而，KD 患者的血小板计数、ESR 和 CRP 明显高于参照患者（P<0.05）。ESR 的截断值为 15 mm/hr 时，其敏感性为 93.9%，特异性为 83.3%，曲线下面积（AUC）为 89.1%（P=0.03）。血小板计数的截断值为 336.5×10(9)/l 时，其敏感性为 70.6%，特异性为 75%，AUC 为 71.2%（P=0.03）。
结论
这些结果表明，血小板计数和 ESR 是 KD 的良好预测指标。
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