Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, USA.
J Am Chem Soc. 2010 Dec 15;132(49):17405-7. doi: 10.1021/ja109253t. Epub 2010 Nov 19.
A "safety-catch" linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol nucleophile that can be released using acid generated at the microelectrodes.
已使用“安全扣”连接体策略从微电极阵列中选择性切割和分析分子。连接体通过酯键连接到阵列上,并包含受保护的胺基或受保护的醇亲核试剂,可使用在微电极上产生的酸将其释放。