神经节苷脂（克朗纳西亚尔）治疗对糖尿病大鼠胰岛MHC Ia抗原表达及同种异体移植存活的影响。
Effects of ganglioside (Cronassial) treatment on MHC Ia antigen expression and allograft survival of pancreatic islets in diabetic rats.
作者信息
Bretzel R G, Flesch B K, Willig J, Woehrle M, Federlin K
机构信息
3rd Medical Department, Justus-Liebig-University of Giessen, FRG.
出版信息
Diabetologia. 1990 Feb;33(2):112-4. doi: 10.1007/BF00401049.
Streptozotocin-diabetic BdII rats were treated daily with 20 mg/kg body weight gangliosides for ten days beginning two days before transplantation. This treatment did not prolong allograft survival of untreated Lewis islets. Culture treatment of isolated Lewis islets with gangliosides (100 micrograms/ml in RPMI 1640) for one day resulted in a significant reduction of MHC Ia antigen positive cells but not of class I antigens within the islets. Transplantation of the ganglioside pretreated islets into non-immunosuppressed BdII recipients prolonged allograft survival to 12 days only in one of five animals.
链脲佐菌素诱导糖尿病的BdII大鼠在移植前两天开始，每天接受20毫克/千克体重的神经节苷脂治疗，持续十天。这种治疗并未延长未治疗的Lewis胰岛的同种异体移植存活时间。用神经节苷脂（在RPMI 1640中为100微克/毫升）对分离的Lewis胰岛进行一天的培养处理，导致胰岛内MHC Ia抗原阳性细胞显著减少，但I类抗原未减少。将经神经节苷脂预处理的胰岛移植到未进行免疫抑制的BdII受体中，仅在五只动物中的一只中使同种异体移植存活时间延长至12天。
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