Shakya Vikal C, Agrawal Chandra S, Shrestha Pramod, Poudel Prakash, Khaniya Sudeep, Adhikary Shailesh
Department of Surgery, B, P, Koirala Institute of Health Sciences, Dharan, Nepal.
BMC Surg. 2010 Nov 26;10:35. doi: 10.1186/1471-2482-10-35.
Intestinal atresia is a common cause of neonatal intestinal obstruction, and management of this disease in limited setup of a developing country is very difficult.
This study is a retrospective study of patients with jejunoileal atresias and their postoperative outcome in a teaching hospital in eastern Nepal over a 5-year period.
There were 28 children (19 boys and 9 girls). 11 children (39.28%) had jejunal atresia and 17 (60.71%) had ileal atresia. Eight (28.5%) patients died, 6 were jejunal atresia (54.5%) and 2 were ileal atresia (11.7%). The most common cause of death was sepsis which occurred in 7 out of 8 cases (87.5%). The risk factors for mortality identified were leucopenia, neutropenia, delay in surgery, location of atresia and type of atresia. Jejunal atresia tended to have a higher mortality than ileal atresia, and severe types of atresia (type IIIb and IV) were more often associated with mortality than other types of atresia. The significant differences between jejunal and ileal atresia were the increased duration between presentation and surgery, longer postoperative and total hospital stay, presence of more severe atresias and an increased risk of mortality in case of jejunal atresias.
The prognosis for this disease have definitely changed in the last few decades in developed countries but in our environment, problems like late presentation and diagnosis, lack of availability of good neonatal intensive care units and parenteral nutritional support still prevail.
肠道闭锁是新生儿肠梗阻的常见原因,在发展中国家有限的医疗条件下,这种疾病的治疗非常困难。
本研究是对尼泊尔东部一家教学医院5年间空回肠闭锁患者及其术后结局的回顾性研究。
共有28名儿童(19名男孩和9名女孩)。11名儿童(39.28%)为空肠闭锁,17名(60.71%)为回肠闭锁。8名(28.5%)患者死亡,其中6名是空肠闭锁(54.5%),2名是回肠闭锁(11.7%)。最常见的死亡原因是败血症,8例中有7例(87.5%)发生败血症。确定的死亡危险因素包括白细胞减少、中性粒细胞减少、手术延迟、闭锁部位和闭锁类型。空肠闭锁的死亡率往往高于回肠闭锁,严重类型的闭锁(IIIb型和IV型)比其他类型的闭锁更常与死亡相关。空肠闭锁和回肠闭锁之间的显著差异在于就诊至手术的时间延长、术后和住院总时间延长、严重闭锁更多见以及空肠闭锁时死亡风险增加。
在过去几十年里,发达国家这种疾病的预后肯定有所改变,但在我们的环境中,就诊和诊断延迟、缺乏优质新生儿重症监护病房和肠外营养支持等问题仍然普遍存在。