大体临床分期 Ia 期上皮性卵巢癌中淋巴结转移：哈塞泰佩经验和文献复习。

Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature.

机构信息

Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Ankara, Turkey.

出版信息

World J Surg Oncol. 2010 Nov 30;8:106. doi: 10.1186/1477-7819-8-106.

DOI:10.1186/1477-7819-8-106

PMID:21114870

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3002346/

Abstract

BACKGROUND

Lymphadenectomy is an integral part of the staging system of epithelial ovarian cancer. However, the extent of lymphadenectomy in the early stages of ovarian cancer is controversial. The objective of this study was to identify the lymph node involvement in unilateral epithelial ovarian cancer apparently confined to the one ovary (clinical stage Ia).

METHODS

A prospective study of clinical stage I ovarian cancer patients is presented. Patient's characteristics and tumor histopathology were the variables evaluated.

RESULTS

Thirty three ovarian cancer patients with intact ovarian capsule were evaluated. Intraoperatively, neither of the patients had surface involvement, adhesions, ascites or palpable lymph nodes (supposed to be clinical stage Ia). The mean age of the study group was 55.3 ± 11.8. All patients were surgically staged and have undergone a systematic pelvic and paraaortic lymphadenectomy. Final surgicopathologic reports revealed capsular involvement in seven patients (21.2%), contralateral ovarian involvement in two (6%) and omental metastasis in one (3%) patient. There were two patients (6%) with lymph node involvement. One of the two lymph node metastasis was solely in paraaortic node and the other metastasis was in ipsilateral pelvic lymph node. Ovarian capsule was intact in all of the patients with lymph node involvement and the tumor was grade 3.

CONCLUSION

In clinical stage Ia ovarian cancer patients, there may be a risk of paraaortic and pelvic lymph node metastasis. Further studies with larger sample size are needed for an exact conclusion.

摘要

背景

淋巴结切除术是上皮性卵巢癌分期系统的一个组成部分。然而，在卵巢癌的早期阶段进行淋巴结切除术的范围存在争议。本研究的目的是确定单侧上皮性卵巢癌（临床分期 Ia）局限于一侧卵巢的淋巴结受累情况。

方法

本研究为一项临床分期 I 期卵巢癌患者的前瞻性研究。评估了患者的特征和肿瘤组织病理学。

结果

33 例卵巢癌患者卵巢包膜完整，术中未见表面受累、粘连、腹水或可触及的淋巴结（假定为临床分期 Ia）。研究组的平均年龄为 55.3 ± 11.8 岁。所有患者均接受手术分期，并进行了系统的盆腔和腹主动脉旁淋巴结切除术。最终的手术病理报告显示 7 例（21.2%）患者包膜受累，2 例（6%）对侧卵巢受累，1 例（3%）患者出现网膜转移。有 2 例（6%）患者发生淋巴结受累。其中 1 例仅为腹主动脉旁淋巴结转移，另 1 例为同侧盆腔淋巴结转移。所有发生淋巴结转移的患者卵巢包膜均完整，肿瘤分级为 3 级。