McDermott Center for Human Growth and Development and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Am J Med Sci. 2010 Dec;340(6):481-91. doi: 10.1097/MAJ.0b013e3181ccb980.
Diet and sedentary lifestyle, interacting with "thrifty" genes, are widely accepted as the principal cause of the current global obesity epidemic. However, a number of alternative etiologies for obesity have been proposed, including "drifty" genes, viruses, bacteria, environmental toxins, social network effects, maternal imprinting, sleep deprivation, and others. These Grand Rounds reviews the background of some of these unconventional ideas and evidence for or against their roles in the obesity epidemic.
饮食和久坐的生活方式,与“节俭”基因相互作用,被广泛认为是当前全球肥胖流行的主要原因。然而,人们提出了许多肥胖的其他病因,包括“漂移”基因、病毒、细菌、环境毒素、社交网络效应、母性印迹、睡眠剥夺等。这些大查房回顾了其中一些非传统观点的背景,以及它们在肥胖流行中的作用的证据。