曼氏血吸虫感染对小鼠抗异源抗原免疫反应的影响
[Effect of Schistosoma mansoni infection on the immune reactions against heterologous antigens in mice].
作者信息
Sauer H, Salman H, Ambrosius H, Schäffner H
机构信息
Abteilung für Tropenmedizin, Karl-Marx-Universität Leipzig.
出版信息
Allerg Immunol (Leipz). 1990;36(1):25-36.
Mice (BALB/c or ICR) were infected with Schistosoma mansoni cercariae. After different intervals (mostly eight weeks) the following antigens were injected: a) sheep erythrocytes--b) DNP-thyroglobulin. Afterwards the immune response against these antigens were checked by means of different methods (plaque assay, haemagglutination test, rosette technique). Immune responses to these antigens were depressed in all cases compared to age matched uninfected mice but it was not possible to transfer this immunosuppression with spleen cells to normal or to irradiated recipients.
将BALB/c或ICR小鼠感染曼氏血吸虫尾蚴。在不同时间间隔（大多为8周）后，注射以下抗原：a）绵羊红细胞——b）二硝基苯基甲状腺球蛋白。之后，通过不同方法（空斑试验、血凝试验、玫瑰花结技术）检测针对这些抗原的免疫反应。与年龄匹配的未感染小鼠相比，所有情况下对这些抗原的免疫反应均受到抑制，但无法将这种免疫抑制通过脾细胞转移给正常或经辐射的受体。
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