高密度脂蛋白颗粒、冠心病和烟酸。

High-density lipoprotein particles, coronary heart disease, and niacin.

机构信息

Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111, USA.

出版信息

J Clin Lipidol. 2010 Sep-Oct;4(5):405-10. doi: 10.1016/j.jacl.2010.08.012. Epub 2010 Aug 19.

DOI:10.1016/j.jacl.2010.08.012

Abstract

The use of statins in patients with high risk for cardiovascular disease (CVD) has resulted in a 30-40% decrease in clinical events in the last couple of decades. However, despite of a marked reduction (up to 60%) in LDL-C, about 30% of patients continue to have CVD events. This high residual risk in statin-treated patients initiated the search for new ways to reduce CVD risk. HDL is the next logical target. Epidemiological and cross-sectional studies identified low HDL-C level as an independent risk for CVD. Based on the Framingham Heart Study data, HDL-C <35 mg/dl was established an independent risk factor and HDL-C >60 mg/dl as protective.(3) Presently the cut point is <40 mg/dl for men and <50 mg/dl for women.

摘要

在过去几十年中，使用他汀类药物治疗心血管疾病（CVD）高危患者可使临床事件减少 30-40%。然而，尽管 LDL-C 显著降低（高达 60%），但仍有大约 30%的患者继续发生 CVD 事件。他汀类药物治疗患者的这种高残余风险促使人们寻找新的方法来降低 CVD 风险。HDL 是下一个合乎逻辑的目标。流行病学和横断面研究表明，低 HDL-C 水平是 CVD 的独立危险因素。基于弗雷明汉心脏研究的数据，将 HDL-C<35mg/dl 确定为独立危险因素，而 HDL-C>60mg/dl 则为保护性因素。（3）目前，男性的切点为<40mg/dl，女性的切点为<50mg/dl。