在链条上工作：E3 协同作用进行泛素化。
Working on a chain: E3s ganging up for ubiquitylation.
出版信息
Nat Cell Biol. 2010 Dec;12(12):1124-6. doi: 10.1038/ncb1210-1124.
PMID:21124306
Abstract
Substrate specificity in ubiquitylation is conferred by ubiquitin ligases (E3s). Now, several ways that E3s can interact to mediate ubiquitylation are illustrated for Ubr1 (a RING finger E3) and Ufd4 (a HECT domain E3), in Saccharomyces cerevisiae. These interactions and the related concept of E4 activity are discussed.
摘要
泛素连接酶（E3s）赋予泛素化的底物特异性。现在，以酿酒酵母中的 Ubr1（一种 RING 指 E3）和 Ufd4（一种 HECT 结构域 E3）为例，说明了 E3 相互作用介导泛素化的几种方式。讨论了这些相互作用和相关的 E4 活性概念。
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