[模拟缺氧对小鼠红细胞介电特性的影响]
[Effects of simulated hypoxia on dielectric properties of mouse erythrocytes].
作者信息
Ma Qing, Tang Zhi-Yuan, Wang Qin-Wen, Zhao Xin
机构信息
Institute of Physiology and Pharmacology, Medical School of Ningho University, Ningbo 315211, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008 Feb;24(1):90-4.
AIM
To explore the influence of simulated altitude hypoxia on dielectric properties of mouse erythrocytes.
METHODS
Experimental animals were divided into the plain control group(control) and simulated altitude hypoxia group (altitude). The AC impedance of mouse erythrocytes was measured with the Agilent 4294A impedance analyzer, the influence of simulated altitude hypoxia on dielectric properties of mouse erythrocytes was observed by cell dielectric spectroscopy, Cole-Cole plots, loss factor spectrum, loss tangent spectrum, and curve fitting analysis of Cole-Cole equation.
RESULTS
After mice were exposed to hypoxia at simulated 5000 m altitude for 4 weeks, permittivity at low frequency (epsilonl) and dielectric increment (deltaepsilon) increased 57% and 59% than that of control group respectively, conductivity at low frequency (kappal) and conductivity at high frequency (kappah) reduced 49% and 11% than that of control group respectively.
CONCLUSION
The simulated altitude hypoxia could arise to increase dielectric capability and depress conductive performance on mouse erythrocytes.
目的
探讨模拟高原低氧对小鼠红细胞介电特性的影响。
方法
将实验动物分为平原对照组（对照组）和模拟高原低氧组（低氧组）。用安捷伦4294A阻抗分析仪测量小鼠红细胞的交流阻抗，通过细胞介电谱、Cole-Cole图、损耗因子谱、损耗角正切谱以及Cole-Cole方程的曲线拟合分析，观察模拟高原低氧对小鼠红细胞介电特性的影响。
结果
小鼠在模拟海拔5000米低氧环境下暴露4周后，低频介电常数（εl）和介电增量（δε）分别比对照组增加了57%和59%，低频电导率（κl）和高频电导率（κh）分别比对照组降低了49%和11%。
结论
模拟高原低氧可导致小鼠红细胞介电能力增强和导电性能降低。
Zotero 插件