[石膏对猫视前区/下丘脑前部经致热原处理的热敏神经元放电的影响]
[Effects of gypsum on the firing of pyrogen-treated thermosensitive neurons in PO/AH of cats].
作者信息
Wang Yan, Yang Yu, Bai Xia, Sun Li-Hua, Wu Yu-Huan, Yang Cheng-Liang
机构信息
Department of Physiology, China Medical University, Shenyang 110001, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008 Aug;24(3):320-3.
AIM
To investigate the possible central mechanism of antipyretic effects of Chinese medicine gypsum.
METHODS
Gypsum was injected after the fever model was established. The firing rate of thermosensitive neurons in preoptic-anterior hypothalamus(PO/AH) region was recorded by using extracellular microelectrode technique.
RESULTS
The injection of pyrogen evoked decrease in firing rate of the warm-sensitive neurons and increase in the cold-sensitive neurons in the region of PO/AH; the changes of the firing rate of pyrogen- treated warm-sensitive and cold-sensitive neurons could be reversed by the injection of gypsum.
CONCLUSION
The result may suggest that antipyretic action of gypsum is mediated by its influences on the thermosensitivity neurons in the region of PO/AH.
目的
探讨中药石膏解热作用的可能中枢机制。
方法
在发热模型建立后注射石膏。采用细胞外微电极技术记录视前区-下丘脑前部（PO/AH）区域热敏神经元的放电频率。
结果
注射致热原后，PO/AH区域温敏神经元放电频率降低，冷敏神经元放电频率增加；注射石膏可逆转致热原处理的温敏和冷敏神经元放电频率的变化。
结论
该结果可能提示石膏的解热作用是通过其对视前区-下丘脑前部区域热敏神经元的影响介导的。
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