三通道脑电图导联在新生儿癫痫发作检测和定量中的应用。

Three-channel electroencephalogram montage in neonatal seizure detection and quantification.

机构信息

Department of Neurology, University of California at San Diego and Rady Children's Hospital, San Diego, California 92123, USA.

出版信息

Pediatr Neurol. 2011 Jan;44(1):31-4. doi: 10.1016/j.pediatrneurol.2010.08.014.

DOI:10.1016/j.pediatrneurol.2010.08.014

PMID:21147384

Abstract

We compared three-channel montage with 21-channel neonatal minimal placement montage for the detection of neonatal seizures and quantification of seizure burden. Thirty-five neonatal electroencephalograms were retrospectively and blindly reviewed by two independent readers. Tracings were analyzed in the three-channel montage for seizure number, duration, and quantification of seizure burden before reanalysis with the full 21-channel neonatal minimal placement montage. Seizures were identified using standard definitions of electroencephalographic seizure. Sensitivity, specificity, and interrater reliability were calculated. The sensitivity and specificity of three-channel montage for detecting seizures > 10 seconds were 91% and 100% for reader 1, respectively, and 82% and 96% for reader 2, respectively. The interrater agreement for detection of seizures was excellent (κ = 0.86, 94% percent overall agreement). For quantification of seizure burden, strong, positive correlation existed between assessments by full montage and three-channel montage (for reader 1, r = 0.945, n = 11, P < 0.0001; for reader 2, r = 0.902, n = 11, P < 0.0001), and strong correlation existed between the readers for three-channel montage (r = 0.879, n = 11, P < 0.0001). Despite its limitations, three-channel montage is useful in the detection of neonatal seizures and quantification of seizure burden.

摘要

我们比较了三通道电极帽与 21 通道新生儿最小安置电极帽在检测新生儿癫痫发作和量化癫痫发作负担方面的作用。两位独立的读者回顾性和盲目地审查了 35 例新生儿脑电图。在使用完整的 21 通道新生儿最小安置电极帽重新分析之前，对三通道电极帽中的描记进行了癫痫发作数量、持续时间和癫痫发作负担的量化分析。使用脑电图癫痫发作的标准定义来识别癫痫发作。计算了敏感性、特异性和组内一致性。对于> 10 秒的癫痫发作，三通道电极帽检测的敏感性和特异性分别为读者 1 的 91%和 100%，读者 2 的 82%和 96%。检测癫痫发作的组内一致性非常好（κ = 0.86，总体一致性为 94%）。对于癫痫发作负担的量化，全图和三通道图的评估之间存在很强的正相关（对于读者 1，r = 0.945，n = 11，P < 0.0001；对于读者 2，r = 0.902，n = 11，P < 0.0001），并且两位读者之间的三通道图也存在很强的相关性（r = 0.879，n = 11，P < 0.0001）。尽管存在局限性，但三通道电极帽在检测新生儿癫痫发作和量化癫痫发作负担方面是有用的。