蔓越莓汁未能预防复发性尿路感染：一项随机安慰剂对照试验的结果。
Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomized placebo-controlled trial.
机构信息
Department of Epidemiology, Center for Molecular and Clinical Epidemiology of Infectious Diseases, University of Michigan School of Public Health, Ann Arbor, Michigan 48109–2029, USA.
出版信息
Clin Infect Dis. 2011 Jan 1;52(1):23-30. doi: 10.1093/cid/ciq073.
BACKGROUND
A number of observational studies and a few small or open randomized clinical trials suggest that the American cranberry may decrease incidence of recurring urinary tract infection (UTI).
METHODS
We conducted a double-blind, placebo-controlled trial of the effects of cranberry on risk of recurring UTI among 319 college women presenting with an acute UTI. Participants were followed up until a second UTI or for 6 months, whichever came first. A UTI was defined on the basis of the combination of symptoms and a urine culture positive for a known uropathogen. The study was designed to detect a 2-fold difference between treated and placebo groups, as was detected in unblinded trials. We assumed 30% of participants would experience a UTI during the follow-up period.
RESULTS
Overall, the recurrence rate was 16.9% (95% confidence interval, 12.8%-21.0%), and the distribution of the recurrences was similar between study groups, with the active cranberry group presenting a slightly higher recurrence rate (20.0% vs 14.0%). The presence of urinary symptoms at 3 days, 1-2 weeks, and at ≥ 1 month was similar between study groups, with overall no marked differences. CONCLUSIONS.: Among otherwise healthy college women with an acute UTI, those drinking 8 oz of 27% cranberry juice twice daily did not experience a decrease in the 6-month incidence of a second UTI, compared with those drinking a placebo.
背景
一些观察性研究和少数小型或开放性随机临床试验表明，蔓越莓可能会降低复发性尿路感染（UTI）的发生率。
方法
我们对 319 名出现急性 UTI 的女大学生进行了一项双盲、安慰剂对照试验，以评估蔓越莓对复发性 UTI 风险的影响。参与者随访至第二次 UTI 或随访 6 个月（以先发生者为准）。UTI 的定义是基于症状和尿液培养出已知尿路病原体的阳性结果。该研究旨在检测治疗组和安慰剂组之间 2 倍的差异，这与非盲试验中检测到的结果一致。我们假设在随访期间，30%的参与者会发生 UTI。
结果
总的来说，复发率为 16.9%（95%置信区间，12.8%-21.0%），且复发的分布在两组之间相似，活性蔓越莓组的复发率略高（20.0%比 14.0%）。研究组之间 3 天、1-2 周和≥1 个月时的尿路症状存在情况相似，总体上没有明显差异。结论：在没有其他健康问题的女大学生中，与饮用安慰剂者相比，每天饮用 8 盎司 27%蔓越莓汁两次并没有降低 6 个月内第二次 UTI 的发生率。
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