Marín Gabriel M A, Bergón Sendín E, Melgar Bonís A, García Lara N, Rosa Pallás Alonso C, de la Cruz Bértolo J
Departamento de Neonatología, Hospital Universitario 12 de Octubre, Madrid, Spain.
An Pediatr (Barc). 2011 Feb;74(2):84-90. doi: 10.1016/j.anpedi.2010.09.018. Epub 2010 Dec 18.
Adverse neurological events in very low birth weight (VLBW) children with bronchopulmonary dysplasia (BPD) are more frequent than in children without. An understanding of the ages when preterm infants acquire certain motor skills will give parents more appropriate information on motor development. The objective of the present study is to estimate the influence between BPD and the age of acquisition of sitting unsupported and independent walking in VLBW children with normal neurological examination at 2 years of corrected age.
A longitudinal study was conducted on a cohort of 885 children with VLBW, admitted to the Hospital "12 de Octubre" between January 1991 and December 2003. Age for both skills was established by interview with parents. Means were compared with t-test and Bonferroni adjustment where appropriate.
Both motor skills were acquired later in the group with BPD (7.8±2m vs. 7.1±1.3m for sitting unsupported and 14.5±3.8m vs. 13.4±2.5m for walking) (P<.001). BPD was associated with delayed acquisition (above p90) of these skills, OR=2.6 (1.6-4.1) for sitting and OR=2.8 (1.6-4.8) for walking. Association was found after adjusting for gestational age (GA) and weight.
BPD was associated with delayed acquisition of both skills in VLBW children with normal neurological examination at 2 years.
患有支气管肺发育不良(BPD)的极低出生体重(VLBW)儿童发生不良神经事件的频率高于未患此病的儿童。了解早产儿获得某些运动技能的年龄将为家长提供有关运动发育的更合适信息。本研究的目的是评估BPD与矫正年龄2岁时神经检查正常的VLBW儿童获得独坐和独立行走能力的年龄之间的影响。
对1991年1月至2003年12月间入住“十月十二日”医院的885名VLBW儿童队列进行了一项纵向研究。通过与家长访谈确定两种技能的获得年龄。必要时采用t检验和Bonferroni校正比较均值。
BPD组获得两种运动技能的时间均较晚(独坐:7.8±2个月 vs. 7.1±1.3个月;行走:14.5±3.8个月 vs. 13.4±2.5个月)(P<.001)。BPD与这些技能的延迟获得(高于第90百分位数)相关,独坐的OR=2.6(1.6 - 4.1),行走的OR=2.8(1.6 - 4.8)。在对胎龄(GA)和体重进行校正后发现存在关联。
BPD与矫正年龄2岁时神经检查正常的VLBW儿童两种技能的延迟获得相关。