Department of Ophthalmology, University of Bonn, Germany.
Acta Ophthalmol. 2011 Feb;89(1):70-5. doi: 10.1111/j.1755-3768.2010.02064.x. Epub 2010 Dec 22.
To determine the incidence of rhegmatogenous retinal detachments (RD) after intravitreal injection in six high-volume centres.
A consecutive, interventional, multicenter case series measured the incidence of RD in patients receiving intravitreal anti-VEGF. A total of 35 942 intravitreal anti-VEGF injections (the number of the injections determined by review of injection log books over a 3 year period) were performed under sterile conditions with the patient in a supine position. Injections were given 3.5-4.0 mm behind the limbus in a tunnelled fashion.
During 36 consecutive months, five RD were reported, between 2 and 6 days after the injection. Of the affected eyes, four were myopic -1.75 to -5.5 dpt. The incidence rate of rhegmatogenous RD was 0.013% (5/35 942) per injection.
The incidence of RD in our community setting was very low (1 per 7188 injections). All RD occurred during the early postoperative period. The risks of RD can be minimized by a careful injection technique.
在六个大容量中心确定玻璃体内注射后孔源性视网膜脱离（RD）的发生率。
一项连续的、干预性的、多中心病例系列研究测量了接受玻璃体内抗 VEGF 治疗的患者中 RD 的发生率。共进行了 35942 例玻璃体内抗 VEGF 注射（通过审查 3 年期间的注射记录簿确定注射次数），在无菌条件下，患者取仰卧位进行注射。注射在 3.5-4.0mm 后进行，在隧道式进行。
在 36 个月的连续时间内，报告了 5 例 RD，发生在注射后 2 至 6 天。受影响的眼睛中，有四只近视 -1.75 至 -5.5dpt。孔源性 RD 的发生率为每注射 0.013%（5/35942）。
在我们的社区环境中，RD 的发生率非常低（每 7188 次注射 1 次）。所有 RD 均发生在术后早期。通过仔细的注射技术可以将 RD 的风险降到最低。
