Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China.
Int J Immunogenet. 2010 Oct;37(5):393-6. doi: 10.1111/j.1744-313X.2010.00939.x. Epub 2010 Jun 21.
Interleukin-1 receptor antagonist (IL-1Ra) has been supposed to play important roles in pregnancy. The purpose of this study was to evaluate the association between the polymorphisms of IL-1Ra gene (IL1RN) variable number tandem repeat (VNTR) in intron 2 with idiopathic recurrent spontaneous abortion (RSA). Ninety-two RSA patients and hundred normal women with at least one live birth and no history of miscarriage were included in the study. Frequencies of the IL1RN alleles and genotypes were determined. Data revealed that the prevalence of IL1RN allele and genotype was not significant between the RSA and control group (all P > 0.05). Our finding indicated that the polymorphism VNTR of IL1RN gene in intron 2 may not be a risk factor for RSA in the Chinese Han population.
白细胞介素-1 受体拮抗剂（IL-1Ra）被认为在妊娠中发挥重要作用。本研究旨在评估白细胞介素-1 受体拮抗剂基因（IL1RN）内含子 2 中的可变数目串联重复（VNTR）多态性与特发性复发性自然流产（RSA）之间的关系。本研究纳入了 92 例 RSA 患者和 100 名至少有一次活产且无流产史的正常女性。确定了 IL1RN 等位基因和基因型的频率。结果显示，IL1RN 等位基因和基因型在 RSA 组和对照组之间无显著差异（均 P > 0.05）。我们的发现表明，白细胞介素-1 受体拮抗剂基因内含子 2 中的 VNTR 多态性可能不是汉族人群 RSA 的危险因素。
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