基因组学在心血管医学中的作用。
Role of genomics in cardiovascular medicine.
作者信息
Novelli Giuseppe, Predazzi Irene M, Mango Ruggiero, Romeo Francesco, Mehta Jawahar L
机构信息
Giuseppe Novelli, Irene M Predazzi, Department of Biopathology and Diagnostic Imaging, Section of Medical Genetics, School of Medicine, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy.
出版信息
World J Cardiol. 2010 Dec 26;2(12):428-36. doi: 10.4330/wjc.v2.i12.428.
As all branches of science grow and new experimental techniques become readily accessible, our knowledge of medicine is likely to increase exponentially in the coming years. Recently developed technologies have revolutionized our analytical capacities, leading to vast knowledge of many genes or genomic regions involved in the pathogenesis of congenital heart diseases, which are often associated with other genetic syndromes, coronary artery disease and non-ischemic cardiomyopathies and channelopathies. The knowledge-base of the genesis of cardiovascular diseases is likely going to be further revolutionized in this new era of genomic medicine. Here, we review the advances that have been made over the last several years in this field and discuss different genetic mechanisms that have been shown to underlie a variety of cardiovascular diseases.
随着所有科学分支的发展以及新的实验技术变得易于获取，在未来几年我们对医学的认知可能会呈指数级增长。最近开发的技术已经彻底改变了我们的分析能力，使我们对许多参与先天性心脏病发病机制的基因或基因组区域有了广泛的了解，先天性心脏病常与其他遗传综合征、冠状动脉疾病、非缺血性心肌病和通道病相关。在这个基因组医学的新时代，心血管疾病发生机制的知识库可能会进一步发生变革。在此，我们回顾过去几年该领域取得的进展，并讨论已被证明是多种心血管疾病基础的不同遗传机制。
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