在包含 DGKI 的 7q33 区域中的 SNP 变异与芬兰和德国人群中的阅读障碍有关。
SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations.
机构信息
Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Hälsovägen 7, S-141 83 Huddinge, Sweden.
出版信息
Behav Genet. 2011 Jan;41(1):134-40. doi: 10.1007/s10519-010-9431-4. Epub 2011 Jan 4.
Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota (DGKI) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets.
四个基因，DYX1C1、ROBO1、DCDC2 和 KIAA0319，已经在遗传和功能上被研究为发育性阅读障碍的候选基因，这是一种儿童常见的学习障碍。识别新的基因对于更好地理解阅读障碍个体受影响的分子途径至关重要。在这里，我们报告了在芬兰和德国阅读障碍群体中进行连锁和关联分析的精细映射方法的结果。我们将候选区域限制在 7q33 染色体上的 0.3Mb 内。这个区域包含了与芬兰和德国样本集中的阅读障碍相关的重叠单倍型的基因二酰基甘油激酶，iota（DGKI）。
Zotero 插件