开胸和闭胸猪模型中心电图记录的比较。
Comparison of electrocardiographic recordings in open-chest and closed-chest swine models.
作者信息
Shousha Sherif, Diodati Jean G, de Chantal Marilyn, Charron Thierry, Amyot Robert, Schampaert Erick, Pharand Chantal
机构信息
Research Center, Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada.
出版信息
J Am Assoc Lab Anim Sci. 2010 Nov;49(6):852-5.
The aim of our study was to compare the electrocardiographic recordings in an experimental open-chest swine model before and after left-sided thoracotomy to detect any surgery-induced fluctuations that might interfere with subsequent experimental interventions. We obtained electrocardiograms from 8 deeply anesthetized domestic swine and compared the respective ST-segment potentials obtained after vascular surgery and after left-sided thoracotomy and dissection of the left anterior descending coronary artery. Compared with baseline recordings, no significant ST-segment deviation on any of the electrocardiographic leads occurred after vascular surgery. However, statistically significant ST-segment depression was observed after thoracotomy. Invasive surgical procedures in open-chest swine models may lead to morphologic changes in the ST segment. The physiologic mechanism of these changes is not fully understood.
我们研究的目的是比较在实验性开胸猪模型中左侧胸廓切开术前和术后的心电图记录，以检测任何可能干扰后续实验干预的手术引起的波动。我们从8只深度麻醉的家猪身上获取心电图，并比较血管手术后、左侧胸廓切开术以及解剖左冠状动脉前降支后获得的各自ST段电位。与基线记录相比，血管手术后任何心电图导联均未出现显著的ST段偏移。然而，胸廓切开术后观察到有统计学意义的ST段压低。开胸猪模型中的侵入性外科手术可能会导致ST段形态改变。这些变化的生理机制尚未完全了解。
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