未治疗精神分裂症患者尾状核体积减小：神经发育病因发病机制的证据。
Reduced Caudate Volume in Never-Treated Schizophrenia : Evidence for Neuro developmental Etiopathogenesis.
机构信息
GANESAN VENKATASUBRAMANIAN, Department Of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
出版信息
Indian J Psychiatry. 2003 Apr;45(2):20-6.
BACKGROUND
Evidence suggests that caudate nucleus abnormalities have a role in schizophrenia. Structural brain imaging studies on caudate size in schizophrenia are inconclusive due to confounding factors.
METHODS
In this study, caudate volume was measured on coronal Magnetic Resonance Images (I -mm) in consenting 15 never-treated schizophrenia (DSM-IV) patients and 15 age, sex, handedness, education and socioeconomic status matched controls using semi-automated Scion image software.
RESULTS
Multivariate analysis revealed significantly smaller caudate volume in patients than controls after controlling for intracranial area (df = 2,27; F = 5.4; p = 0.028). Separate univariate analysis showed that right (df = 2,27; F = 5.4; p = 0.028) and left (df = 2,27; F = 5.2; p = 0.031) caudate were significantly smaller in patients than controls after controlling for intracranial area. Illness duration did not correlate significantly with either right (r = - 0.13; p = 0.65) or left (r = - 0.10; p = 0.7) caudate volume.
DISCUSSION
Significantly smaller caudate nucleus in patients with never-treated schizophrenia suggests that some aspect of the disease process of schizophrenia influences the caudate nucleus. In conclusion, smaller caudate volume in never treated schizophrenia with lack of correlation between illness duration and caudate size supports neuro developmental etiopathogenesis in schizophrenia.
背景
有证据表明，尾状核异常与精神分裂症有关。由于混杂因素的影响，精神分裂症尾状核大小的结构性脑影像学研究尚无定论。
方法
在这项研究中，使用 Scion 图像软件，对 15 名未经治疗的精神分裂症（DSM-IV）患者和 15 名年龄、性别、利手、教育和社会经济地位匹配的对照者的冠状磁共振图像（I-mm）进行了半自动化测量，计算尾状核体积。
结果
多变量分析显示，在控制颅内面积后，患者的尾状核体积明显小于对照组（df = 2,27；F = 5.4；p = 0.028）。单独的单变量分析显示，在控制颅内面积后，患者的右侧（df = 2,27；F = 5.4；p = 0.028）和左侧（df = 2,27；F = 5.2；p = 0.031）尾状核体积明显小于对照组。病程与右侧（r = - 0.13；p = 0.65）或左侧（r = - 0.10；p = 0.7）尾状核体积均无显著相关性。
讨论
未经治疗的精神分裂症患者尾状核体积明显较小，表明精神分裂症的某些疾病过程会影响尾状核。总之，未经治疗的精神分裂症患者尾状核体积较小，且病程与尾状核大小之间缺乏相关性，支持精神分裂症的神经发育病因假说。
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