4H-色烯、香豆素、12H-色烯并[2,3-d]嘧啶衍生物的合成及其部分抗菌和细胞毒性活性。
Synthesis of 4H-chromene, coumarin, 12H-chromeno[2,3-d]pyrimidine derivatives and some of their antimicrobial and cytotoxicity activities.
机构信息
Chemistry Department, Girls College of Education, King Khalid University, Abha, Saudi Arabia.
出版信息
Eur J Med Chem. 2011 Feb;46(2):765-72. doi: 10.1016/j.ejmech.2010.12.015. Epub 2010 Dec 21.
Condensation of 3-N,N-diethylaminophenol (1) with α-cyanocinnamonitriles (2a-c) and ethyl α-cyanocinnamates (2d-f) provided compounds 3a-f and 4a-c. 12H-Chromeno[2,3-d]pyrimidine derivatives 6, 11-13 and 16 were obtained by treatment of 4H-chromene compounds (3) with different electrophiles followed by nucleophilic reagents. Structures of these compounds were established on the basis of IR, UV, 1H NMR, 13C NMR and MS data. Some of the new compounds were evaluated for antimicrobial and cytotoxicity activities.
3-N,N-二乙基氨基酚（1）与α-氰基肉桂腈（2a-c）和α-氰基肉桂酸乙酯（2d-f）缩合得到化合物 3a-f 和 4a-c。用不同的亲电试剂处理 4H-色烯化合物（3）后，得到 12H-色烯并[2,3-d]嘧啶衍生物 6、11-13 和 16。这些化合物的结构是基于 IR、UV、1H NMR、13C NMR 和 MS 数据确定的。部分新化合物进行了抗菌和细胞毒性活性评价。
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