¹¹C-胆碱显像作为 F-18 FDG PET 显像的补充在甲状腺癌探测中的应用。
Utility of ¹¹C-choline imaging as a supplement to F-18 FDG PET imaging for detection of thyroid carcinoma.
机构信息
NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
出版信息
Clin Nucl Med. 2011 Feb;36(2):91-5. doi: 10.1097/RLU.0b013e318203bb55.
PURPOSE
We present 4 patients with thyroid carcinoma who underwent ¹¹C-choline PET/CT for the detection of their primary tumor and its metastases. Previous F-18 FDG PET had shown no abnormal tracer uptake in the lesions in 3 patients and only mild uptake in 1 patient.
MATERIALS AND METHODS
Four patients aged between 24 and 59 years (2 newly diagnosed and 2 with recurrence) underwent whole-body F-18 FDG PET/CT. The patients then underwent regional ¹¹C-choline PET/CT imaging on a separate day.
RESULTS
All of the lesions in 4 patients were ¹¹C-choline avid except for a few small lung metastases. The SUVmax of the lesions was 7.94 ± 4.93. ¹¹C-choline imaging detected 3 primary tumors in 4 patients, 1 tumor in the tracheal wall in 1 patient, 7 cervical lymph nodes metastases in 3 patients, and several lung metastases in 1 patient.
CONCLUSIONS
¹¹C-choline PET/CT may be a promising supplement to F-18 FDG PET/CT in the detection of thyroid carcinoma and its metastases.
目的
我们报告了 4 例甲状腺癌患者，他们接受了 ¹¹C-胆碱 PET/CT 检查以检测原发肿瘤及其转移灶。此前的 F-18 FDG PET 在 3 例患者的病变中未显示异常示踪剂摄取，仅在 1 例患者中显示轻度摄取。
材料和方法
4 名年龄在 24 至 59 岁之间的患者（2 例为初诊，2 例为复发）接受了全身 F-18 FDG PET/CT 检查。然后，这些患者在另一天进行了局部 ¹¹C-胆碱 PET/CT 成像。
结果
除了少数小的肺转移灶外，4 例患者的所有病变均对 ¹¹C-胆碱有摄取。病变的 SUVmax 为 7.94±4.93。¹¹C-胆碱成像在 4 例患者中发现了 3 个原发肿瘤，1 例患者的气管壁有 1 个肿瘤，3 例患者有 7 个颈部淋巴结转移，1 例患者有多个肺部转移。
结论
¹¹C-胆碱 PET/CT 可能是 F-18 FDG PET/CT 检测甲状腺癌及其转移灶的一种有前途的补充方法。
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