18F-FDG PET 阳性的肺门和纵隔淋巴结肿大，在接受干扰素-α-2b 治疗的黑色素瘤患者中类似于转移性疾病。

F-18 FDG PET positive hilar and mediastinal lymphadenopathy mimicking metastatic disease in a melanoma patient treated with interferon-alpha-2b.

机构信息

Division of Nuclear Medicine, Department of Radiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, USA.

出版信息

Clin Nucl Med. 2011 Feb;36(2):154-5. doi: 10.1097/RLU.0b013e318203bea5.

DOI:10.1097/RLU.0b013e318203bea5

PMID:21220988

Abstract

A 49-year-old man with a history of recurrent melanoma in the parotid was treated with parotidectomy, external beam radiation, and high-dose interferon-alpha-2b. Combined F-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) performed for restaging demonstrated multiple bilateral hilar and mediastinal hypermetabolic foci corresponding to hilar and mediastinal lymphadenopathy. Cytologic specimens obtained by bronchoscopy were negative for malignancy, revealing reactive lymph nodes. Subsequent FDG PET/CT showed regression of the findings. Awareness of possible interferon-associated reaction in melanoma patients who undergo FDG PET is important to avoid pitfalls in the interpretation.

摘要

一位 49 岁男性，有复发性腮腺黑色素瘤病史，曾接受腮腺切除术、外照射和高剂量干扰素-α-2b 治疗。为了进行重新分期，对其进行了 F-18 氟脱氧葡萄糖正电子发射断层扫描和计算机断层扫描（FDG PET/CT），结果显示双侧肺门和纵隔多个高代谢病灶，对应肺门和纵隔淋巴结病。支气管镜取得的细胞学标本未见恶性肿瘤，显示为反应性淋巴结。随后的 FDG PET/CT 显示发现物消退。在对接受 FDG PET 的黑色素瘤患者进行解读时，了解可能与干扰素相关的反应很重要，以避免出现解释上的错误。