男性促黄体生成素释放激素脉冲发生器：异常情况与临床管理

The luteinizing hormone-releasing hormone pulse generator in men: abnormalities and clinical management.

作者信息

Matsumoto A M, Gross K M, Sheckter C B, Bremner W J

机构信息

Gerontology Research, Education, and Clinical Center, VA Medical Center, GRECC, Seattle, WA 98108.

出版信息

Am J Obstet Gynecol. 1990 Nov;163(5 Pt 2):1743-52. doi: 10.1016/0002-9378(90)91439-j.

DOI:10.1016/0002-9378(90)91439-j

PMID:2122731

Abstract

Most men with hypogonadotropic eunuchoidism have absent luteinizing hormone and presumably absent luteinizing hormone-releasing hormone pulses. Pulsatile luteinizing hormone-releasing hormone therapy is effective in restoring normal gonadotropin secretion and testicular function and inducing fertility in men with hypogonadotropic eunuchoidism. Furthermore, pulsatile (versus continuous) luteinizing hormone-releasing stimulation of the pituitary gland is an absolute requirement for normal gonadotropin secretion. Men with idiopathic oligoazoospermia and selective elevation of follicle-stimulating hormone levels have slow luteinizing hormone and presumably luteinizing hormone-releasing pulse frequency. In these men, pulsatile luteinizing hormone--releasing treatment is effective in decreasing serum follicle-stimulating hormone levels, but it is unclear whether spermatogenesis and fertility are improved.

摘要

大多数低促性腺激素性类无睾症男性缺乏促黄体生成素，推测也缺乏促黄体生成素释放激素脉冲。脉冲式促黄体生成素释放激素疗法可有效恢复低促性腺激素性类无睾症男性的正常促性腺激素分泌和睾丸功能，并诱导生育。此外，对垂体进行脉冲式（而非持续性）促黄体生成素释放刺激是正常促性腺激素分泌的绝对必要条件。特发性少弱精子症且卵泡刺激素水平选择性升高的男性，其促黄体生成素分泌缓慢，推测促黄体生成素释放脉冲频率也较低。对于这些男性，脉冲式促黄体生成素释放治疗可有效降低血清卵泡刺激素水平，但目前尚不清楚精子发生和生育能力是否得到改善。