脂蛋白(a)与心肌梗死风险——因果关系的遗传流行病学证据。
Lipoprotein(a) and risk of myocardial infarction--genetic epidemiologic evidence of causality.
机构信息
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
出版信息
Scand J Clin Lab Invest. 2011 Apr;71(2):87-93. doi: 10.3109/00365513.2010.550311. Epub 2011 Jan 13.
Elevated levels of lipoprotein(a) are associated with an increased risk of myocardial infarction. Our study aimed to test whether genetic data are consistent with this association being causal. Accordingly, we developed a high-throughput realtime PCR assay to genotype for the lipoprotein(a) kringle IV type 2 (KIV-2) repeat polymorphism in the LPA gene in > 40,000 individuals. The LPA KIV-2 genotype associated with plasma levels of lipoprotein(a) (trend p < 0.001), and the LPA KIV-2 genotype associated with risk of myocardial infarction (trend p < 0.001 to 0.03) in a manner consistent with its effect on plasma levels of lipoprotein(a). The association of LPA KIV-2 genotypes raising plasma levels of lipoprotein(a) with increased risk of myocardial infarction strongly supports a causal association of lipoprotein(a) with risk of myocardial infarction.
脂蛋白(a)水平升高与心肌梗死风险增加有关。我们的研究旨在测试遗传数据是否与这种关联的因果关系一致。因此，我们开发了一种高通量实时 PCR 测定法，用于对 LPA 基因中的脂蛋白(a)kringle IV 型 2（KIV-2）重复多态性进行基因分型，对 > 40,000 个人进行基因分型。LPA KIV-2 基因型与脂蛋白(a)的血浆水平相关（趋势 p < 0.001），并且 LPA KIV-2 基因型与心肌梗死的风险相关（趋势 p < 0.001 至 0.03），与对脂蛋白(a)的血浆水平的影响一致。LPA KIV-2 基因型升高脂蛋白(a)的血浆水平与心肌梗死风险增加之间的关联强烈支持脂蛋白(a)与心肌梗死风险之间的因果关系。
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