Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA.
Rev Endocr Metab Disord. 2010 Dec;11(4):237-51. doi: 10.1007/s11154-010-9154-0.
Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5. There are many causes for osteopenia including calcium and vitamin D deficiency and inactivity. Genetics plays an important role in a person's bone mineral density and often Caucasian women with a thin body habitus who are premenopausal are found to have osteopenia. Correction of calcium and vitamin D deficiency and walking 3 to 5 miles a week can often improve bone density in the hip and spine. There are a variety of pharmaceutical agents that have been recommended for the treatment of osteopenia and osteoporosis including hormone replacement therapy, selective estrogen receptor modulator therapy, anti-resorptive therapy. In addition patients with osteoporosis who have failed anti-resorptive therapy can have a significant improvement in their bone density with anabolic therapy.
骨质疏松症是一个定义,用于描述骨密度不正常但又未达到骨质疏松症程度的状态。根据世界卫生组织的定义,骨质疏松症通过骨密度测定法定义为 T 评分-1 至-2.5。骨质疏松症有许多原因,包括钙和维生素 D 缺乏以及缺乏运动。遗传在一个人的骨矿物质密度中起着重要作用,通常白人女性,体型偏瘦,绝经前,会发现患有骨质疏松症。钙和维生素 D 缺乏的纠正以及每周步行 3 到 5 英里,通常可以改善髋关节和脊柱的骨密度。有多种药物被推荐用于治疗骨质疏松症和骨质疏松症,包括激素替代疗法、选择性雌激素受体调节剂疗法、抗吸收疗法。此外,对于抗吸收疗法失败的骨质疏松症患者,使用合成代谢疗法可显著提高骨密度。