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骨质疏松症的诊断与治疗。

Diagnosis and treatment of osteopenia.

机构信息

Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA.

出版信息

Rev Endocr Metab Disord. 2010 Dec;11(4):237-51. doi: 10.1007/s11154-010-9154-0.

Abstract

Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5. There are many causes for osteopenia including calcium and vitamin D deficiency and inactivity. Genetics plays an important role in a person's bone mineral density and often Caucasian women with a thin body habitus who are premenopausal are found to have osteopenia. Correction of calcium and vitamin D deficiency and walking 3 to 5 miles a week can often improve bone density in the hip and spine. There are a variety of pharmaceutical agents that have been recommended for the treatment of osteopenia and osteoporosis including hormone replacement therapy, selective estrogen receptor modulator therapy, anti-resorptive therapy. In addition patients with osteoporosis who have failed anti-resorptive therapy can have a significant improvement in their bone density with anabolic therapy.

摘要

骨质疏松症是一个定义,用于描述骨密度不正常但又未达到骨质疏松症程度的状态。根据世界卫生组织的定义,骨质疏松症通过骨密度测定法定义为 T 评分-1 至-2.5。骨质疏松症有许多原因,包括钙和维生素 D 缺乏以及缺乏运动。遗传在一个人的骨矿物质密度中起着重要作用,通常白人女性,体型偏瘦,绝经前,会发现患有骨质疏松症。钙和维生素 D 缺乏的纠正以及每周步行 3 到 5 英里,通常可以改善髋关节和脊柱的骨密度。有多种药物被推荐用于治疗骨质疏松症和骨质疏松症,包括激素替代疗法、选择性雌激素受体调节剂疗法、抗吸收疗法。此外,对于抗吸收疗法失败的骨质疏松症患者,使用合成代谢疗法可显著提高骨密度。

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