新生儿窒息后急性肾损伤。

Acute kidney injury post neonatal asphyxia.

机构信息

Children's Hospital at Westmead, Sydney, New South Wales, Australia.

出版信息

J Pediatr. 2011 Feb;158(2 Suppl):e29-33. doi: 10.1016/j.jpeds.2010.11.010.

DOI:10.1016/j.jpeds.2010.11.010

Abstract

Acute kidney injury (AKI) is a common consequence of perinatal asphyxia, occurring in up to 56% of these infants. A major difficulty in diagnosing this condition is the lack of a consensus definition of neonatal AKI, largely because of a dearth of specific measurable variables and biochemical markers. This review will discuss the current evidence regarding the epidemiology, investigation, and treatment of AKI in the asphyxiated neonate. Particular emphasis will be given to the investigation of renal function in the neonate and to potential biomarkers that may aid the clinician in the diagnosis of renal injury in this population.

摘要

急性肾损伤（AKI）是围产期窒息的常见后果，在多达 56%的此类婴儿中发生。诊断这种情况的主要困难是缺乏新生儿 AKI 的共识定义，这主要是由于缺乏具体的可测量变量和生化标志物。这篇综述将讨论目前关于窒息新生儿 AKI 的流行病学、检查和治疗的证据。特别强调了对新生儿肾功能的检查以及可能有助于临床医生在该人群中诊断肾损伤的潜在生物标志物。