一种天然产物样的 NEDD8 激活酶抑制剂。
A natural product-like inhibitor of NEDD8-activating enzyme.
机构信息
Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
出版信息
Chem Commun (Camb). 2011 Mar 7;47(9):2511-3. doi: 10.1039/c0cc04927a. Epub 2011 Jan 14.
PMID:21240405
Abstract
The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.
摘要
天然产物样 6,6″-双芹菜素被鉴定为使用虚拟筛选方法鉴定的第二种 NEDD8-激活酶抑制剂。该化合物在酶和基于细胞的测定中具有活性，其效力在微摩尔范围内。
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