Laser and Skin Surgery Center of Indiana, Carmel, Indiana 46032, USA.
Dermatol Ther. 2011 Jan-Feb;24(1):62-70. doi: 10.1111/j.1529-8019.2010.01379.x.
Extrinsic aging of the hands involves alterations in pigmentation, wrinkling, and texture as a result of chronic ultraviolet and environmental exposures. Inherent tissue properties of the skin of the dorsal hand have made it challenging to safely and effectively improve all three parameters of photoaging with a single device. Recent successes with non-ablative fractional lasers on the hands, as well as success of ablative fractional lasers on the neck and chest, raise the question of potential efficacy of ablative lasers for photorejuvenation of the hands. This was a prospective pilot study of ablative fractional CO(2) laser in 10 participants, each receiving three treatments to one hand at 4-6-week intervals. Subjective assessments by investigator and participants were performed 1 month after each treatment. At 1-month follow-up after final treatment, investigators rated mean improvement of 26-50% for wrinkles, 51-75% for pigment, and 26-50% for texture. Participants rated mean improvement after final treatment as 26-50% for wrinkles, 51-75% for pigment, and 51-75% for texture. Other than significant edema noted in one participant after the first treatment, side effects were limited to transient erythema and edema, with no long-term scarring or pigmentary alteration. In this pilot study, ablative fractional resurfacing was safe and effective for the treatment of all markers of extrinsic aging of the hands. A high degree of improvement was achieved in two to three treatments with no long-term sequelae.
手部的外在老化涉及色素沉着、皱纹和纹理的改变，这是由于慢性紫外线和环境暴露造成的。由于手背皮肤的固有组织特性，很难使用单一设备安全有效地改善所有三种光老化参数。最近非剥脱性分束激光在手背上的成功，以及剥脱性分束激光在颈部和胸部的成功，引发了关于剥脱性激光对手部光老化的潜在疗效的问题。这是一项前瞻性的研究，共纳入 10 名参与者，每只手接受三次治疗，间隔 4-6 周。治疗后 1 个月由研究者和参与者进行主观评估。最后一次治疗后 1 个月的随访中，研究者评估皱纹的平均改善率为 26%-50%，色素沉着的平均改善率为 51%-75%，纹理的平均改善率为 26%-50%。参与者在最后一次治疗后评价皱纹的平均改善率为 26%-50%，色素沉着的平均改善率为 51%-75%，纹理的平均改善率为 51%-75%。除了一名参与者在第一次治疗后出现明显水肿外，副作用仅限于短暂的红斑和水肿，没有长期的瘢痕或色素改变。在这项初步研究中，剥脱性分束激光对治疗手部外在老化的所有标志都是安全有效的。在两到三次治疗后即可达到高度改善，且无长期后遗症。
