Can Fam Physician. 1984 Sep;30:1905-12.
A 44-year-old man presented to his family physician with intrahepatic cholestatic jaundice, which he had had for seven days. He was admitted to the Family Medicine Service of University Hospital, Saskatoon, and the jaundice was extensively investigated. Initially, it was thought to be induced by antibiotics, but this was not confirmed on controlled drug rechallenge. The precise cause was not found. This article outlines a rational and systematic method for investigating obstructive jaundice. The method and importance of drug rechallenges to identify drugs suspected of causing cholestasis are reviewed.
一位 44 岁男性因肝内胆汁淤积性黄疸至家庭医生处就诊,黄疸已持续 7 天。他被收入萨斯卡通大学医院家庭医学科,对黄疸进行了广泛的检查。最初,黄疸被认为是由抗生素引起的,但在药物控制再激发试验中并未得到证实。确切的病因未找到。本文概述了一种合理且系统的方法来调查梗阻性黄疸。本文还回顾了药物再激发试验以确定可疑引起胆汁淤积药物的方法和重要性。