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胰腺坏死组织清除术的微创方法。

Minimally invasive approach to pancreatic necrosectomy.

作者信息

Wani Sachin V, Patankar Roy V, Mathur S K

机构信息

Joy Hospital Pvt. Ltd., Institute for Special Surgery, Mumbai, India.

出版信息

J Laparoendosc Adv Surg Tech A. 2011 Mar;21(2):131-6. doi: 10.1089/lap.2010.0401. Epub 2011 Feb 1.

Abstract

BACKGROUND

Conventional open surgery for infected pancreatic necrosis is associated with significant surgical morbidity, that is, wound complications, facial dehiscence, and intestinal fistulae. In recent years, there has been interest in attempting to reduce this surgical morbidity by adopting a number of minimally invasive approaches.

METHODS

Fifteen patients with pancreatic necrosis underwent pancreatic necrosectomy by minimally invasive surgery (11 men, 4 women; age group: 25-64 years, mean age: 46 years). Apache II scores ranged from 5 to 14. Pancreatic necrosectomy was performed by laparoscopic transperitoneal approach in 12 patients (transmesocolic, 4 patients; transgastrocolic, 6 patients; and gastrohepatic omentum, 2 patients), by retroperitoneal approach in 2 patients, and by a combination of methods in 1 patient (endoscopic transgastric drainage followed by laparoscopic intracavity necrosectomy). Relook laparoscopy was done in 5 patients to assess for residual necrosis.

RESULTS

All the patients tolerated the procedure well, and there was no mortality. Two of them had pancreatic fistula, which eventually responded to conservative treatment. Three patients were converted to open necrosectomy because of bleeding or difficulty to access the area of necrosis. The mean operating time was 120 ± 10 minutes. There were no postoperative complications related to the procedure itself, such as major wound infections, intestinal fistulae, or postoperative hemorrhage. Postoperative computed tomographic scans confirmed adequacy of debridement. The average length of hospital stay after surgery was 14 days.

CONCLUSIONS

Minimally invasive necrosectomy is technically feasible and a body of evidence now suggests that acceptable outcomes can be achieved. There are no comparisons of results available, either with open surgery or among different minimally invasive techniques.

摘要

背景

传统开放性手术治疗感染性胰腺坏死会导致严重的手术并发症,即伤口并发症、切口裂开和肠瘘。近年来,人们对通过采用多种微创方法来降低这种手术并发症产生了兴趣。

方法

15例胰腺坏死患者接受了微创手术下的胰腺坏死组织清除术(11例男性,4例女性;年龄范围:25 - 64岁,平均年龄:46岁)。急性生理与慢性健康状况评分系统(Apache II)评分范围为5至14分。12例患者通过腹腔镜经腹腔途径进行胰腺坏死组织清除术(经结肠系膜途径4例;经胃结肠途径6例;经胃肝网膜途径2例),2例患者通过腹膜后途径进行,1例患者采用联合方法(内镜经胃引流后行腹腔镜腔内坏死组织清除术)。5例患者接受了再次腹腔镜检查以评估残余坏死情况。

结果

所有患者对手术耐受性良好,无死亡病例。其中2例发生胰瘘,但最终经保守治疗痊愈。3例患者因出血或难以到达坏死区域而转为开放性坏死组织清除术。平均手术时间为120 ± 10分钟。没有出现与手术本身相关的术后并发症,如严重伤口感染、肠瘘或术后出血。术后计算机断层扫描证实清创充分。术后平均住院时间为14天。

结论

微创坏死组织清除术在技术上是可行的,目前有证据表明可以取得可接受的结果。目前尚无与开放性手术或不同微创技术之间的结果比较。

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