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影响临床医生在抽动障碍治疗中决定是否开具精神药物的因素。

Factors affecting clinicians' decision as to whether to prescribe psychotropic medications or not in treatment of tic disorders.

作者信息

Kuwabara Hitoshi, Kono Toshiaki, Shimada Takafumi, Kano Yukiko

机构信息

Department of Child Psychiatry, The University of Tokyo Hospital, Tokyo, Japan.

出版信息

Brain Dev. 2012 Jan;34(1):39-44. doi: 10.1016/j.braindev.2011.01.003. Epub 2011 Feb 1.

Abstract

Using clinical data, a retrospective investigation was carried out to elucidate factors and/or symptom severity affecting the clinicians' decision-making as to whether or not psychotropic medications should be prescribed for tic disorders. For this purpose, medical records on a total of 75 patients with tic disorders were collected and scrutinized. Of the total, 36 patients were found to have been given psychotropics on their first visit to our facility. With respect to the total scores of motor tics on the YGTSS, vocal tics on the YGTSS, the GAF score and age, the subjects were divided into two groups one with psychotropic medications prescribed and the other without any psychotropic medication at the first examination and compared by use of t-test. With respect to comorbid neuropsychiatric disorders and the sex, the two groups were compared using Chi square test. To see which one of factors had influenced the treating clinicians' decision to use or not to use psychotropic drugs at the first examination, analyses were made using the logistic regression model with those factors assigned for covariants and the prescription or no-prescription of psychotropic medications for dependent variables. Analyses using a logistic regression model revealed that vocal tics (p<0.01) and age (p<0.05) had significant correlations with the use or non-use of psychotropic drugs. This finding suggested that the severity degree of vocal tics might play the most important role as a factor that affects the clinicians' initial treatment plan with or without psychotropic drugs. And clinicians tend to avoid a drug therapy on younger children.

摘要

利用临床数据进行了一项回顾性调查,以阐明影响临床医生决定是否应为抽动障碍患者开具精神药物的因素和/或症状严重程度。为此,收集并仔细审查了总共75例抽动障碍患者的病历。其中,36例患者在首次到我们机构就诊时就接受了精神药物治疗。根据耶鲁综合抽动严重程度量表(YGTSS)上的运动抽动总分、YGTSS上的发声抽动、大体功能评定量表(GAF)得分和年龄,将受试者分为两组,一组在首次检查时接受了精神药物治疗,另一组未接受任何精神药物治疗,并使用t检验进行比较。对于共病的神经精神障碍和性别,使用卡方检验对两组进行比较。为了确定在首次检查时哪些因素影响了治疗临床医生使用或不使用精神药物的决定,使用逻辑回归模型进行分析,将这些因素作为协变量,将精神药物的处方或未处方作为因变量。使用逻辑回归模型的分析显示,发声抽动(p<0.01)和年龄(p<0.05)与精神药物的使用或不使用有显著相关性。这一发现表明,发声抽动的严重程度可能是影响临床医生初始治疗计划(使用或不使用精神药物)的最重要因素。而且临床医生倾向于避免对年幼儿童进行药物治疗。

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