西多福韦治疗非典型人乳头瘤病毒相关上皮增生的新疗法。
Novel treatment of atypical human papillomavirus-associated epithelial hyperplasia with cidofovir.
作者信息
Collette David C, Zechel Marc A
机构信息
Department of Oral and Maxillofacial Surgery, Case School of Dental Medicine and University Hospitals of Cleveland, Cleveland, Ohio, USA.
出版信息
J Oral Maxillofac Surg. 2011 Sep;69(9):2383-6. doi: 10.1016/j.joms.2010.10.040. Epub 2011 Feb 3.
PURPOSE
We report a severe case of human papillomavirus-associated epithelial hyperplasia in a man infected with human immunodeficiency virus. These lesions were recalcitrant to treatment with surgical modalities and were eventually controlled with the daily application of a topical cidofovir gel.
PATIENT AND METHODS
A single case is presented, along with a relevant review of the published data.
RESULTS
Before the initiation of cidofovir treatment, the patient had approximately 80% of his gingiva and buccal mucosa engrossed by confluent papillomatous lesions. At 2 weeks after cidofovir treatment, the lesions had markedly regressed, and by 4 weeks, they were almost fully resolved. No untoward adverse reactions occurred.
CONCLUSIONS
Cidofovir formulated as a gel can be safe and effective for the treatment of epithelial hyperplasia in those with human immunodeficiency virus infection.
目的
我们报告一例感染人类免疫缺陷病毒的男性患者发生的严重人乳头瘤病毒相关上皮增生病例。这些病变对手术治疗方法反应不佳，最终通过每日外用西多福韦凝胶得到控制。
患者与方法
报告一例病例，并对已发表的数据进行相关综述。
结果
在开始西多福韦治疗前，患者约80%的牙龈和颊黏膜被融合性乳头状病变占据。西多福韦治疗2周后，病变明显消退，4周时几乎完全消退。未发生不良不良反应。
结论
制成凝胶剂型的西多福韦对于治疗人类免疫缺陷病毒感染患者的上皮增生可能是安全有效的。
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